Quinine – Natural Alkaloid for Antimalarial, Antipyretic & Bitter Applications

Botanical Origin: Cinchona spp. bark
CAS Number: 130-95-0
Molecular Formula: C₂₀H₂₄N₂O₂
Molecular Weight: 324.42 g/mol
Form: White to light-yellow crystalline powder
Purity: ≥99.0% Total Base (HPLC)
Grade: Pharmaceutical & industrial grade available

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🧬 What is Quinine?

Quinine is a naturally occurring cinchona alkaloid extracted from the bark of Cinchona trees, historically used to treat malaria. Today, it remains valuable for fever relief, muscle cramp prevention, and as a bitter flavoring agent in foods and beverages like tonic water.

It exhibits a unique bitter profile, along with antipyretic, analgesic, antiplasmodial, and antiviral properties, making it versatile across pharma, functional foods, and cosmetic applications.

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🧪 Specification of Quinine ≥99%​

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💧 Solubility

• Water: Slightly soluble

• Ethanol: Freely soluble

• Organic solvents: Soluble in chloroform and ether
  🔍 Suitable for solutions, emulsions, capsules, or flavor infusions

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🌿 Key Benefits & Functions of Quinine

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🌿 Applications & Use Cases

1. Pharmaceuticals

• Use: Antimalarial (quinine sulfate), muscle relaxant, fever reducer

• Benefits:

  • Effective against Plasmodium falciparum

  • Used in tonic muscle cramp treatment

• Form: Capsules, tablets, injectables

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2. Functional Beverages & Food

• Use: Bittering agent in tonic water and herbal mixers

• Benefits:

  • Intense natural bitterness for balance and complexity

  • Enhances botanical beverage profiles

• Dosage: As per food additive guidelines (typically ≤83 mg/L in beverages)

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3. Cosmetics & Topicals

• Use: Cooling, anti-inflammatory ingredient in lotions and creams

• Benefits:

  • May help with itch relief and localized muscle tension

  • Adds exotic “bitter plant” positioning in skincare

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4. Veterinary & Research

• Used in animal studies and feed-based parasite resistance models

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⚙️ Production Flowchart (Simplified)

1. 🌳 Harvesting Cinchona Bark

2. 🧪 Solvent Extraction

3. ⚗️ Alkaloid Isolation & Fractionation

4. 💎 Crystallization (Quinine Base or Sulfate)

5. 🔬 Drying & HPLC Assay

6. 📦 Packaging & QC Release

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🌍 Why Choose Chibio Biotech for Quinine?

• ✅ ≥99% purity with only 0.5% other alkaloids

• ✅ Strict control over residual solvents and heavy metals

• ✅  ISO 22000:2018, Kosher production standards

• ✅ Available in bulk for pharmaceutical, beverage, and cosmetic uses

• ✅ Comprehensive documentation: COA, MSDS, technical support available

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💼 Why Use Quinine in Your Business?

✅ 1. Versatile Ingredient with Cross-Industry Demand

Quinine serves both pharmaceutical and non-pharmaceutical markets, offering dual value as:

• A regulated medicinal compound in antimalarial and muscle-relief products

• A functional and flavor ingredient in premium beverages and cosmetics

This diversity creates opportunities in:

• Rx and OTC pharma

• Tonic water and herbal mixers

• Natural cosmetics

• Veterinary research

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✅ 2. Natural & Clean-Label Positioning

• Sourced from Cinchona tree bark – a trusted traditional medicinal source

• Appealing for botanical, plant-based, and clean-label product positioning

• Recognized globally as a natural bitter compound

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✅ 3. High Functional Potency in Small Doses

• Strong efficacy even at microgram levels:

  • e.g., tonic water contains only ~83 mg/L of quinine

  • Antimalarial treatments use precise dosing of quinine salts

• Reduces formulation costs while delivering measurable benefits

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✅ 4. Historic & Scientific Credibility

• Over 400 years of use in medicine

• Modern clinical validation for malaria, fever relief, and leg cramp reduction

• Consistent demand in regions with tropical diseases and botanical beverage trends

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✅ 5. Premium Branding Potential

• Enables brands to create heritage-themed, apothecary-style, or bitter-forward beverages and health products

• Adds functional storytelling for consumer trust and engagement

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🔚 Conclusion: Business Use Case Summary

• 📈 Pharmaceutical Companies: Antimalarial and leg cramp OTC products

• 🍹 Beverage Brands: Tonic water, botanical spirits, premium mixers

• 🧴 Cosmetics Manufacturers: Herbal cooling gels, soothing creams

• 🐾 Veterinary Formulators: Anti-parasitic R&D applications

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📩 Looking to add premium Quinine to your pharmaceutical or beverage formulations?
📧 sales@chibiotech.com | 🌐 www.chibiotech.com | 📞 +86 532 66983270
✅ Chibio Biotech – Alkaloid Excellence. Natural Functionality. Precision Quality.