💎 1. Product Introduction

N-Acetylneuraminic Acid (Sialic Acid) is an important functional carbohydrate widely found in human milk oligosaccharides (HMOs), glycoproteins, and gangliosides. It plays a key role in brain development, immune function, and cellular communication.

Chibio Biotech offers two production routes for Sialic Acid:

1. Premium Non-GMO fermentation route – produced through polysialic acid intermediate hydrolysis.

2. Cost-efficient fermentation route – directly produced by microbial fermentation.

Both products achieve ≥98% purity, while offering different advantages in purity control, natural origin positioning, and production cost.

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🧬 2. Basic Information

Item	Details
Product Name	N-Acetylneuraminic Acid
Common Name	Sialic Acid
CAS No.	131-48-6
Molecular Formula	C₁₁H₁₉NO₉
Appearance	White powder
Taste	Slight acidic taste
Grade	Food Grade
Shelf Life	24 months

 

⚗️ 3. Technical Specifications (COA Summary)

Premium Non-GMO Sialic Acid

Parameter	Specification	Result
Sialic Acid Assay	≥98.0%	99.2%
Water Content	≤5.0%	0.47%
Ash	≤2.0%	0.15%
Transmittance	≥98%	98.2%
Lead	≤0.5 mg/kg	Not detected
Total Plate Count	≤500 CFU/g	<10

Direct Fermentation Sialic Acid

Parameter	Specification	Result
Sialic Acid Assay	≥98.0%	99.6%
Water Content	≤5.0%	0.7%
Ash	≤2.0%	0.6%
pH	1.8–2.3	2.0
Lead	≤0.8 mg/kg	<0.1
Total Plate Count	≤1000 CFU/g	Conforms

🔬 4. Production Technology Comparison

📊 Manufacturing Route Comparison

Feature	Premium Sialic Acid	Standard Sialic Acid
Batch Example	GBS-NAASA-Z25070701	GBS-NAASA-T25061501
Production Route	Polysialic Acid → Hydrolysis	Direct Fermentation
GMO Status	Non-GMO strain	Fermentation strain
Intermediate	Polysialic acid	None
Purification Complexity	Higher	Lower
Production Cost	Higher	More economical
Typical Market Position	Infant nutrition / high-end nutraceuticals	General supplements / food ingredients

⚙️ 5. Production Process

Premium Process (Polysialic Acid Route)

According to the flowchart  :

Seed Culture

⬇

Primary Fermentation

⬇

Secondary Fermentation

⬇

Fermentation Broth

⬇

Polysialic Acid Solution

⬇

Acid Liquid Collection

⬇

Hydrolysis

⬇

Purification

⬇

Concentration & Crystallization

⬇

Drying

⬇

Sialic Acid Powder

Key Feature:

Natural bacteria first produce polysialic acid, which is then hydrolyzed into sialic acid.

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Standard Process (Direct Fermentation Route)

According to the flowchart  :

Seed Culture

⬇

Fermentation

⬇

Fermentation Liquid

⬇

Centrifugation

⬇

Purification

⬇

Concentration

⬇

Crystallization

⬇

Drying

⬇

Sialic Acid Powder

Key Feature:

The microorganism directly produces sialic acid without polysialic acid intermediate.

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🧬 6. Functional Benefits

1. Brain Development Support

   Essential component of neural gangliosides and synaptic function.

2. Infant Cognitive Development

   Important nutrient naturally present in human milk.

3. Immune System Support

   Participates in immune cell recognition processes.

4. Gut Microbiota Regulation

   Supports beneficial gut bacteria growth.

5. Cellular Communication

   Plays a role in glycoprotein signaling pathways.

6. Anti-viral & Anti-adhesion Properties

   Can interfere with pathogen attachment mechanisms.

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🧴 7. Applications (Functions & Dosage Guidance)

👶 Infant Nutrition

Function

• Supports brain development

• Mimics human milk oligosaccharide components

• Improves cognitive development potential

Typical Dosage

• 50–300 mg/kg in infant formula.

Preferred Grade

• Premium Non-GMO Sialic Acid

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💊 Nutraceutical Supplements

Function

• Supports cognitive health

• Enhances immune defense

• Promotes neurological function

Typical Dosage

• 50–200 mg/day.

Preferred Grade

• Either grade depending on product positioning.

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🧠 Brain Health & Nootropic Formulas

Function

• Enhances synaptic plasticity

• Supports memory and cognitive function

Typical Dosage

• 100–300 mg/day.

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🧴 Cosmetic Applications

Function

• Improves skin barrier function

• Supports anti-aging formulations

• Enhances cell signaling in skin repair

Typical Inclusion

• 0.1–0.5% in cosmetic formulations.

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🏆 8. Why Choose Chibio Biotech?

International Certifications

Chibio Biotech has obtained:

• ISO 22000 Certification

• HALAL Certification

• KOSHER Certification

• US FDA Food Facility Registration

Ensuring global regulatory compliance.

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Dual Production Technology

• Premium Non-GMO polysialic acid route

• Cost-efficient direct fermentation route

Providing flexible pricing and application solutions.

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Strict Quality Control

• ≥98% purity testing

• Heavy metal monitoring

• Microbiological safety verification

• Batch traceability documentation.

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Stable Global Supply

• Professional fermentation facilities

• Scalable production capacity

• Reliable export logistics.

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11. Summary

Chibio’s N-Acetylneuraminic Acid (Sialic Acid) is available in two advanced production routes: a premium non-GMO polysialic acid hydrolysis process and a cost-efficient direct fermentation process. Both deliver high purity and reliable quality, supporting applications in infant nutrition, cognitive health supplements, and advanced nutraceutical formulations.

📩 Looking for high-quality Sialic Acid for your formulations?

📧 Email: sales@chibiotech.com

📞 Phone: +86 (0)532 66983270

🌍 Website: www.chibiotech.com

✅ Chibio Biotech – Advanced Fermentation Technology for Next-Generation Nutritional Ingredients. 🧬✨

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