Melengestrol Acetate (MGA) – Veterinary-Grade Progestogen for Reproductive & Growth Control

CAS Number: 2919-66-6
Molecular Formula: C₂₅H₃₂O₄
Molecular Weight: 396.52 g/mol
Purity: 99.3%
Form: Light yellow crystalline powder

🔍 1. What is Melengestrol Acetate?

Melengestrol Acetate (MGA) is a synthetic progestogen widely used as a feed additive in veterinary medicine, especially in cattle (heifers). It functions by suppressing estrus (heat) and improving feed efficiency and weight gain in livestock. It is not approved for human use and strictly regulated for animal-only applications.

🧪2.  Specifications of Melengestrol Acetate MGA 99%​

✅ Storage: Cool, dry place; avoid light and heat
✅ Packaging: Secure, light-resistant containers

🌟3. Key Benefits & Functional Advantages

🐄 4. Primary Applications

📌 A. Estrus Suppression in Feedlot Heifers

• Function: Prevents display of estrus (heat) during feeding period

• Advantages:

  • Minimizes aggressive or sexual behavior

  • Reduces injury and handling stress

  • Improves uniformity in growth performance

• Typical Dosage: 0.25–0.50 mg/heifer/day (oral feed inclusion)

📌 B. Growth Promotion & Feed Efficiency

• Function: Enhances average daily gain (ADG) and feed conversion ratio (FCR)

• Mechanism: Stabilizes hormonal environment for optimal muscle growth

• Benefits:

  • Better weight gain over finishing period

  • Reduced feed cost per kg of weight gain

  • Improved carcass quality and profitability

📌 C. Reproductive Synchronization Programs

• Function: Used in conjunction with prostaglandins for controlled ovulation

• Protocols: “MGA-PG” programs for timed artificial insemination

• Advantages:

  • Synchronizes ovulation windows

  • Reduces labor and insemination variability

  • Promotes higher pregnancy rates

📌 MGA is administered via oral feed premix (regulated concentration: typically 0.25–0.5 mg/head/day depending on formulation).

🧬 5. Mechanism of Action

• Mimics natural progesterone

• Suppresses LH surge and ovulation

• Modulates reproductive cycle without adverse behavioral effects

• Can be withdrawn in timed protocols to initiate estrus synchrony

⚠️ 6. Regulatory Considerations

• 📌 For veterinary use only

• 📋 Requires proper feed formulation and residue monitoring

• 🚫 Not approved for dairy cattle or animals intended for breeding

⚙️ 7. Simplified Flowchart: MGA Production Process

1. Synthesis of Steroidal Backbone
   – Starting from progesterone or steroid precursor

2. Selective Acetylation
   – Introduces acetate group at specific position

3. Crystallization & Purification
   – Ensures high purity, isomer control

4. Drying & Milling
   – Achieves ideal particle size & moisture control

5. HPLC & QC Analysis
   – Verifies identity, impurities, purity, loss on drying

6. Packaging
   – Under light-resistant, moisture-proof conditions

📈 8. Why Use Melengestrol Acetate in Business?

• ✅ Enables better control over livestock reproduction, reducing variability

• ✅ Improves feed-to-weight ratio, supporting economic growth in beef production

• ✅ Market-standard growth promotant in North and South America

• ✅ Well-documented safety, efficacy, and cost-effectiveness

• ✅ Chibio Biotech provides high-purity MGA (99.3%) with COA and compliance documentation

🌍 9. Why Choose Chibio Biotech for MGA?

📩 Looking to secure high-grade MGA for veterinary feed formulations?
📧 Email: sales@chibiotech.com | 🌐 www.chibiotech.com | 📞 +86 532 66983270
✅ Chibio Biotech – Trusted Source for Veterinary APIs and Feed Additives