1. Introduction

HMB (β-Hydroxy β-Methyl-Butyric) is a naturally occurring metabolite of the essential amino acid Leucine. It plays a vital role in muscle growth, recovery, and reducing muscle breakdown, making it a popular ingredient in sports nutrition and dietary supplements.

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2. Source & CAS Number

• Source: Derived from Leucine metabolism
• CAS Number: 625-08-1 (HMB Free Acid) / 135236-72-5 (HMB Calcium)

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3. Chemical Structure

HMB Free Acid (FA)

Molecular Formula: C5H10O3
Structure:
🧪 More bioavailable, faster absorption

HMB Calcium (Ca-HMB)

Molecular Formula: C10H18CaO6
Structure:
🦴 More stable, extended release

📌 Both forms support muscle retention, strength, and endurance.

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4. Specifications & Comparison (HMB Ca Powder vs. HMB Liquid)

Item	HMB Ca Powder	HMB Liquid (HMB Free Acid)	Key Differences
Appearance	White crystalline powder	Colorless to yellow liquid	Powder is more stable; liquid absorbs faster
HMB Assay	≥84.0%	≥95.0%	Free acid has higher purity
pH	Neutral	1.0 – 4.0	Liquid is acidic, better for absorption
Calcium Content	13.6-14.8%	None	HMB Ca provides calcium benefits
Solubility	Slightly soluble in water	Highly soluble in water	Liquid dissolves instantly
Heavy Metals	≤10 ppm	≤10 ppm	Both meet strict safety standards
Shelf Life	2 years	2 years	Both have long-term stability
Storage	Dry, cool place	Sealed, away from moisture	Proper storage ensures effectiveness

📌 HMB Ca Powder: Best for stable formulations like capsules & powders.
📌 HMB Liquid (FA): Best for fast-acting liquid supplements & beverages.

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5. Solubility & Stability

• HMB Ca Powder: Slightly soluble in water, better mixed in solid formulations.
• HMB Liquid (FA): Completely water-soluble, allowing for fast absorption.
• Storage: Keep both in dry, sealed containers, away from direct light & heat.

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6. Benefits of HMB

💪 Muscle Growth & Strength – Stimulates protein synthesis and reduces muscle breakdown.
⚡ Faster Recovery – Helps muscles recover quickly after intense workouts.
🔥 Fat Loss & Lean Muscle Retention – Preserves muscle while reducing fat.
🏃 Improves Endurance & Performance – Enhances stamina and exercise capacity.
🛡️ Anti-Catabolic Properties – Protects muscles from stress and overtraining damage.
🦴 Supports Bone Health – HMB Ca provides additional calcium for stronger bones.

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7. Applications of HMB

🏋️ Sports Nutrition – Muscle-building powders, pre/post-workout supplements.
🥤 Functional Beverages – Energy drinks, protein shakes.
💊 Dietary Supplements – Tablets, capsules, effervescent formulations.
🦴 Bone Health Supplements – HMB Ca for osteoporosis prevention.
⚕ Medical Nutrition – Supports muscle maintenance in aging populations.

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8. Flowchart of HMB Ca Powder (β-Hydroxy β-Methyl-Butyric Calcium)

The production process of HMB-Ca (Calcium β-Hydroxy β-Methyl-Butyrate) involves multiple purification and reaction steps to ensure high purity and bioavailability.

📌 Step-by-Step Production Process

1️⃣ Raw Material Oxidation

• Diacetone Alcohol is oxidized using sodium hypochlorite (NaClO).
• This step produces an intermediate that undergoes further reactions.

2️⃣ Neutralization & Concentration

• The reaction product is neutralized with HCl (hydrochloric acid).
• The mixture is concentrated under vacuum to remove excess solvents and by-products.

3️⃣ Extraction & Purification

• The concentrated solution is extracted using ethyl acetate to isolate the desired compound.
• Unwanted impurities are removed in this process.

4️⃣ Filtration & Refinement

• The solution is filtered to remove sodium chloride (NaCl), a by-product.
• The crude HMB is further refined and purified.

5️⃣ Rectification & Isolation of HMB

• The refined HMB undergoes rectification, a purification process to enhance purity.
• The isolated HMB is ready for calcium salt conversion.

6️⃣ Reaction with Calcium Salt

• HMB reacts with calcium hydroxide (Ca(OH)₂) in the presence of ethyl alcohol.
• This forms HMB-Ca (Calcium β-Hydroxy β-Methyl-Butyrate) in a stable crystalline form.

7️⃣ Crystallization & Drying

• The HMB-Ca crystallizes and is dried under vacuum to remove residual solvents and moisture.

8️⃣ Final Processing & Packaging

• The dried crystals undergo crushing and screening to ensure uniform particle size.
• The final HMB-Ca powder is packed in sealed containers, ready for distribution.

📌 Key Features of the HMB-Ca Production Process

✔ High Purity (≥99.0%) – Advanced rectification and filtration ensure minimal impurities.
✔ Stable & Bioavailable – The calcium salt form enhances solubility and stability.
✔ Strict Quality Control – Heavy metal limits and microbial safety checks ensure safe consumption.
✔ Versatile Form – Suitable for capsules, tablets, and powder blends in sports and medical nutrition.

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9. Why Choose Chibio Biotech?

✅ High Purity & Bioavailability – 99% pure HMB for maximum effectiveness.
✅ Multiple Forms Available – HMB Ca Powder & HMB Liquid to suit different formulations.
✅ Certified & Safe – GMO-Free, Non-Irradiated, meets global safety standards.
✅ Customizable Supply – Bulk orders, private labeling, and OEM solutions.
✅ Proven Efficacy – Used by athletes, fitness enthusiasts, and medical professionals worldwide.

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10. Why Should Your Business Consider HMB?

📈 Expanding Sports Nutrition Market – Growing demand for muscle-enhancing supplements.
🌍 Scientific Validation – Extensive research backing HMB’s role in muscle health.
🏆 Versatile Applications – Ideal for powders, drinks, capsules, and medical nutrition.
🛒 Higher Consumer Demand – Athletes & aging individuals seek muscle-preserving solutions.

💡 Ready to upgrade your sports & health formulations? Let’s work together!

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📩 Get in Touch for Premium HMB!

Looking for high-quality HMB Calcium or HMB Free Acid for your supplements, beverages, or medical applications? 🌿

📧 Email: sales@chibiotech.com
📞 Phone: +86 (0)532 66983270
🌍 Website: www.chibiotech.com
✅ Maximize muscle growth, strength, and recovery with Chibio Biotech’s HMB – The Ultimate Performance Booster! 🚀