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💎 1. Product Introduction

Cyclodextrins are cyclic oligosaccharides derived from starch through enzymatic conversion. They possess a unique hydrophobic cavity and hydrophilic exterior, enabling them to form inclusion complexes with various active ingredients.

Chibio Biotech supplies three major cyclodextrin types:

• Beta-Cyclodextrin (Betadex)

• Hydroxypropyl-Beta-Cyclodextrin (HP-β-CD)

• Gamma-Cyclodextrin (γ-CD)

These materials are widely used in pharmaceuticals, food, nutraceuticals, and cosmetics for solubility enhancement, stability improvement, and controlled release systems.

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🧬 2. Basic Information & CAS Numbers

Product	CAS No.	Standard	Solubility
Beta-Cyclodextrin	7585-39-9	USP-NF	Sparingly soluble in water
Hydroxypropyl-Beta-Cyclodextrin	128446-35-5	USP-NF 2024	Freely soluble in water
Gamma-Cyclodextrin	17465-86-0	Enterprise Standard	Freely soluble in water

⚗️ 3. Technical Specifications Overview

📊 Comparison Table

Parameter	Beta-CD	HP-β-CD	Gamma-CD
Appearance	White crystalline powder	White amorphous/crystalline powder	White crystalline powder
Assay	98.0–102.0%	Controlled substitution	98.0–102.0%
Water Content	≤14%	≤10%	≤11%
Residue on Ignition	≤0.1%	—	≤0.1%
Impurity Control	Strict related substances control	Betadex ≤1.5%	Alpha/Beta-CD ≤0.5%
Microbial Limits	USP compliant	USP compliant	≤10² cfu/g

💧 4. Functional Characteristics

Beta-Cyclodextrin

• Moderate cavity size

• Improves stability of hydrophobic compounds

• Suitable for solid inclusion complexes

Hydroxypropyl-Beta-Cyclodextrin

• Excellent water solubility

• Ideal for injectable & liquid formulations

• Reduced crystallinity

Gamma-Cyclodextrin

• Largest cavity size

• Superior solubilization capacity

• Better for larger molecular actives

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🧬 5. Core Functional Benefits

1. Solubility Enhancement

2. Improved Bioavailability

3. Odor & Taste Masking

4. Stability Protection Against Oxidation

5. Controlled Release Properties

6. Reduced Irritation Potential

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🧴 6. Applications (With Functional Role & Dosage Guidance)

💊 Pharmaceutical Applications

Function:

• Solubilizing poorly soluble APIs

• Stabilizing volatile or sensitive compounds

• Enhancing drug bioavailability

Typical Usage Level:

• 5–20% of formulation weight (oral solid)

• 1–10% in liquid systems

• HP-β-CD commonly used in injectable systems

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🧴 Cosmetic Applications

Function:

• Encapsulation of fragrances

• Stabilization of retinol & actives

• Reduction of skin irritation

Typical Inclusion:

• 0.5–5% depending on active load

HP-β-CD is preferred for aqueous cosmetic systems.

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🍹 Food & Nutraceutical Applications

Function:

• Masking bitterness

• Protecting sensitive nutrients

• Improving dispersibility of fat-soluble ingredients

Usage Level:

• 0.5–3% in food systems

• 5–15% relative to active ingredient for encapsulation

Gamma-CD preferred for high bioavailability nutraceuticals.

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🌿 Essential Oil & Flavor Encapsulation

Function:

• Volatility control

• Oxidation protection

• Controlled release

Typical Ratio:

• 1:1 to 1:3 (active:cyclodextrin) depending on molecular size

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⚙️ 7. Production Overview

Starch Enzymatic Conversion

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Cyclization via Cyclodextrin Glycosyltransferase

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Purification

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Drying

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Milling

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USP / Enterprise Standard Testing

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Packaging

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🏆 8. Why Choose Chibio Biotech?

USP-Compliant Manufacturing

• Beta-CD & HP-β-CD manufactured under USP-NF standards   

Strict Impurity Control

• Controlled related substances

• Low microbial counts

• Low residual solvents

Flexible Packaging Options

• 20kg / 10kg / 1kg / 0.1kg options 

Stable Large-Scale Production

• 10,000 kg Beta-CD batch capability 

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11. Summary

Chibio’s Cyclodextrin Series (Beta, Hydroxypropyl Beta, and Gamma) provides high-purity, low-impurity inclusion complex solutions for pharmaceutical, food, cosmetic, and nutraceutical applications. With USP-compliant production and strict microbial control, our cyclodextrins deliver reliable performance in solubility enhancement and stability improvement systems worldwide.

📩 Looking for high-performance cyclodextrins for your formulation?

📧 Email: sales@chibiotech.com

📞 Phone: +86 (0)532 66983270

🌍 Website: www.chibiotech.com

✅ Chibio Biotech – Advanced Inclusion Technology for Modern Formulation Science. 🔬✨