🔬 Crospovidone / Polyvinylpolypyrrolidone (PVPP)

High-Performance Disintegrant & Clarifying Agent for Pharmaceutical and Beverage Applications

Crospovidone, also known as Polyvinylpolypyrrolidone (PVPP), is a cross-linked polymer of polyvinylpyrrolidone widely used as a tablet disintegrant in pharmaceutical formulations and as a clarifying agent in beverage processing such as beer and wine.

Due to its unique cross-linked polymer structure, PVPP is insoluble in water but highly swellable, allowing it to rapidly absorb water and facilitate tablet disintegration while maintaining structural stability.

Chibio Biotech supplies high-quality Crospovidone in both granular and powder forms, manufactured under strict quality control to meet international pharmaceutical and food industry standards.

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📌 1. Basic Information

Item	Details
Product Name	Crospovidone
Chemical Name	Polyvinylpolypyrrolidone (PVPP)
CAS No.	9003-39-8
Molecular Structure	Cross-linked Polyvinylpyrrolidone
Solubility	Practically insoluble in water
Function	Tablet disintegrant / beverage clarifier
Shelf Life	3 years

Both product types comply with quality specifications and microbiological safety standards .

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⚗️ 2. Product Specifications

🧪 Crospovidone Granular (PVPP Granular)

Parameter	Specification	Result
Appearance	White to yellowish granular	White granular
Solubility	Practically insoluble in water	Complies
pH (1% suspension)	5.0 – 8.0	6.7
Loss on Drying	≤5.0%	2.7%
Ash	≤0.10%	0.06%
Free N-vinylpyrrolidone	≤10 ppm	2.8 ppm
Peroxides	≤400 ppm	300 ppm
Heavy Metals	≤10 ppm	<10 ppm
Total Plate Count	≤1000 CFU/g	<10 CFU/g

🧪 Crospovidone XL (PVPP Powder)

Parameter	Specification	Result
Appearance	Hygroscopic white powder	White powder
pH (1% suspension)	5.0 – 8.0	7.2
Peroxides	≤400 ppm	214 ppm
Sulfated Ash	≤0.1%	0.08%
Water-soluble substances	≤1.5%	0.15%
Nitrogen Content	11.0 – 12.8%	11.86%
Particle Size D50	70 – 110 μm	Complies
Loss on Drying	≤5%	2.92%
Total Plate Count	≤1000 CFU/g	<10 CFU/g

Product complies with EP11.0 requirements

🔍 3. Crospovidone Granular vs Crospovidone XL (Comparison)

Feature	Crospovidone Granular	Crospovidone XL Powder
Physical Form	Granular	Fine powder
Particle Size	Larger (5–15 mesh)	~70–110 μm
Main Application	Beverage clarification	Pharmaceutical tablets
Swelling Rate	Moderate	Very rapid
Filtration Properties	Excellent	Moderate
Tablet Disintegration	Good	Excellent
Processing	Easier filtration	Better compression uniformity

Key Difference

• Granular PVPP → preferred for beer and wine clarification due to easier filtration.

• Crospovidone XL powder → preferred for tablet disintegration due to faster swelling and uniform mixing.

🧪 4. Functional Benefits

💊 Tablet Disintegration

Crospovidone rapidly absorbs water and expands, breaking tablets into smaller particles to enhance drug dissolution and bioavailability.

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🍺 Beverage Clarification

PVPP removes polyphenols and tannins, improving clarity and stability in beverages such as beer and wine.

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⚡ Rapid Swelling Capacity

Cross-linked structure allows high water uptake without dissolving, ensuring effective tablet disintegration.

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🛡 Chemical Stability

Crospovidone remains stable across a wide pH range and processing conditions.

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🔬 High Purity

Low residual monomer levels and controlled impurity profiles ensure safe pharmaceutical and food applications.

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🏭 5. Applications

💊 Pharmaceutical Industry

Main functions:

• Tablet disintegrant

• Capsule formulation aid

• Fast dissolving tablets

Typical dosage:

2 – 5% of tablet formulation

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🍺 Beverage Industry

Functions:

• Polyphenol removal

• Haze stabilization

• Flavor preservation

Used in:

• Beer stabilization

• Wine clarification

• Juice clarification

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🧴 Food Processing

Acts as:

• Clarifying agent

• Adsorption agent

• Processing aid

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⚙️ 6. Production Process Overview

Vinylpyrrolidone Polymerization

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Cross-linking Reaction

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Polymer Stabilization

⬇

Particle Size Processing

⬇

Purification

⬇

Drying

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Quality Testing

⬇

Packaging

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📦 7. Packaging & Storage

Standard packaging:

• 25 kg fiber drum

Storage recommendations:

• Store in sealed container

• Avoid moisture exposure

• Room temperature storage

Shelf life:

3 years when properly stored .

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🏆 8. Why Choose Chibio Biotech?

🌍 International Certifications

Chibio Biotech holds:

• ISO 22000

• HALAL Certification

• KOSHER Certification

• US FDA Food Facility Registration

Ensuring global market compliance.

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🔬 Strict Quality Control

• Low residual monomer content

• Controlled peroxide levels

• Pharmaceutical-grade quality assurance

• Batch traceability system

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🚚 Reliable Global Supply

• Large production capacity

• Stable batch quality

• Efficient international logistics

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📊 9. Summary

Chibio’s Crospovidone (PVPP) provides a versatile solution for both pharmaceutical tablet disintegration and beverage clarification applications.

With both granular and powder grades available, manufacturers can select the optimal product depending on processing needs, filtration performance, and disintegration requirements.

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📩 Looking for high-quality Crospovidone for your pharmaceutical or beverage formulations?

📧 Email: sales@chibiotech.com

📞 Phone: +86 (0)532 66983270

🌍 Website: www.chibiotech.com

✅ Chibio Biotech – Trusted Supplier of Pharmaceutical Excipients and Functional Ingredients.