💎 1. Product Introduction

Calcium L-5-methyltetrahydrofolate (Ca 5-MTHF) is the biologically active, methylated form of folate (Vitamin B9). Unlike synthetic folic acid, Ca 5-MTHF does not require enzymatic conversion in the body and is directly bioavailable.

Chibio Biotech supplies high-purity Ca 5-MTHF (CAS# 151533-22-1)  with strict impurity control and stable crystalline quality, making it ideal for advanced nutraceutical, pharmaceutical, and functional food formulations.

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🧬 2. Basic Information

• Product Name: Calcium L-5-methyltetrahydrofolate

• Abbreviation: Ca 5-MTHF

• CAS Number: 151533-22-1 

• Appearance: White to light yellow crystalline powder 

• Manufacturing Standard: Enterprise Standard

• Shelf Life: 12 months 

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⚗️ 3. Technical Specifications

According to the Certificate of Analysis  :

Identification

• IR Identification: Consistent with reference standard

• HPLC Identification: Principle peak retention time matches reference

Physical & Chemical

• Water Content: 6.0%–17.0%

• Residual Solvents (Ethanol): ≤0.5%

• Isomer: ≤0.1%

• Chloride: ≤0.5%

Heavy Metals

• Total Heavy Metals: ≤20 ppm

• Arsenic (As): ≤1.5 ppm

• Lead (Pb): ≤1.0 ppm

• Cadmium (Cd): ≤0.5 ppm

• Mercury (Hg): ≤1.5 ppm

Related Substances

• JK12A (RRT ≈ 0.37): ≤0.1%

• 5-Methyltetrahydrodisoic Acid: Not detectable

• Other Impurities: ≤0.1%

• Total Impurities: ≤0.5%

Assay & Mineral Content

• Assay (Dry Basis): 95.0%–102.0%

• Calcium (Dry Basis): 7.0%–8.5%

The product complies with the enterprise quality standard  .

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💧 4. Solubility & Stability

• Slightly soluble in water

• Sensitive to light and heat; store in cool, dry conditions

• Stable in encapsulated and tablet formulations

• Suitable for premix blending in vitamin formulations

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✅ 5. Key Benefits

1. Active, Bioavailable Folate Form – No metabolic conversion required

2. High Purity (Assay up to 99.8%) 

3. Low Impurity Profile – Total impurities ≤0.5%

4. Stable Calcium Salt Form – Improved stability vs free folate

5. Low Heavy Metal Content – Strict safety compliance

6. Suitable for MTHFR-Sensitive Individuals

7. ISO & KOSHER Certified Manufacturing 

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🧬 6. Functions of Calcium L-5-MTHF

1. Supports DNA Synthesis & Repair

   Essential for nucleotide biosynthesis and cell division.

2. Promotes Healthy Red Blood Cell Formation

   Prevents folate deficiency-related anemia.

3. Supports Prenatal Development

   Critical for neural tube development during pregnancy.

4. Homocysteine Regulation

   Helps convert homocysteine into methionine, supporting cardiovascular health.

5. Methylation Support

   Participates directly in methylation cycles essential for neurological function.

6. Cognitive & Neurological Support

   Supports neurotransmitter synthesis and mental well-being.

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🧴 7. Applications

Prenatal & Maternal Nutrition

• Prenatal capsules

• Pregnancy supplements

• Folate-fortified nutritional formulas

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Cardiovascular Health Products

• Homocysteine management supplements

• B-complex formulations

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General Nutritional Supplements

• Multivitamin tablets

• Capsules & softgels

• Powder sachets

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Functional Foods & Beverages

• Fortified drinks

• Nutritional meal replacements

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Pharmaceutical Preparations

• Prescription folate products

• Therapeutic vitamin formulations

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⚙️ 8. Production Process Overview

Raw Material Synthesis

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Purification & Crystallization

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Drying

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HPLC & IR Identification Testing

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Heavy Metal & Impurity Testing

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Final Packaging

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🏆 9. Why Choose Chibio Biotech?

Certified Quality System

• ISO 9001:2015 certified 

• KOSHER certified 

Strict Quality Control

• HPLC identification & assay verification

• Comprehensive impurity profiling

• Heavy metal compliance

Stable Supply Capacity

• Professional vitamin and active ingredient manufacturing

• Batch-based COA documentation

Professional Technical Support

• Formulation consultation

• Documentation support for export

• Customized packaging options

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11. Summary

Chibio’s Calcium L-5-Methyltetrahydrofolate (Ca 5-MTHF) delivers high bioavailability, controlled impurity levels, and consistent pharmaceutical-grade quality for prenatal, cardiovascular, and advanced nutraceutical applications.

📩 Looking for high-purity active folate for your supplement or pharmaceutical formulations?

📧 Email: sales@chibiotech.com

📞 Phone: +86 (0)532 66983270

🌍 Website: www.chibiotech.com

✅ Chibio Biotech – Advanced Vitamin Solutions for Modern Nutrition. 💊✨