Theacrine (1,3,7,9-tetramethyluric acid) is a purine alkaloid found in cupuacu fruit (Theobroma grandiflorum) and the kucha plant (Camellia assamicavar. kucha), that appears to work in a similar way to caffeine – but with less tolerance.
Theacrine shows anti-inflammatory and analgesic effects and appears to affect adenosine signalling in a manner similar to caffeine. In kucha leaves, theacrine is synthesized from caffeine in what is thought to be a three-step pathway.
A couple of human studies suggest that theacrine may increase mental clarity, boost energy, and improve mood and motivation.
How does Theacrine work?
Researchers have determined that theacrine works in the primary ways: it facilitates adenosinergic neurotransmission.
That means that theacrine enhances physical energy by causing adenosine signaling changes similar to caffeine. It also acts as a adenosine antagonist by causing adenosinergicsignaling, which enhances physical energy even further.
In layman’s terms, that means theacrine boosts physical and mental energy in your body by raising levels of certain neurotransmitters.
Theacrine is commonly found in sports supplements like preworkout formulas. Manufacturers used theacrine for the caffeine-like effects without the unwanted side effects of caffeine.
Here are some of the benefits of theacrine:
Physical And Mental Stimulant
Improve Focus, Memory & Motivation
Reduces Stress And Anxiety
Could Induce Thermogenesis And Facilitate Fat Burning
May Reduce Inflammation & Pain
Can Be Taken For Long Periods Of Time With No Tolerance Buildup
Theacrine could be used for different applications as below:
Pre-Workout, Increasing Energy
Improve Focus, Memory & Motivatio
Relieving Inflammation & Pain
Improving Mood, Help with Depression
Reduce Stress & Anxiety
Theacrine raw materials was usually mixed with other ingredients to process to be ready-to-eat products in form like: dietary supplement (capsule / tablet), energy drink or powder.
Theacrine VS Caffeine
Theacrine significant advantages, compared to Caffeine, makes Theacrine uniqueand being great commercial-potential ingredient of alternative Caffeine.
Theacrine works in a similar way to caffeine. Chemically speaking, here’s what the two chemicals look like:
Theacrine’s chemical name is 1,3,7,9-tetramethyluric acid
Caffeine’s chemical name is 1,3,7-trimethylxanthine
The main difference between the two chemicals is that one has an additional methyl group and an additional ketone group.
What makes theacrine truly unique is how it differs from caffeine. Theacrine:
Has a longer half-life
Has no effect on blood pressure
Is less likely to disrupt sleep compared to caffeine
Has reduced tolerance
Caffeine is known to cause a comedown effect after a couple of hours, which leads to even more fatigue. This ultimately leads to drinking more coffee or taking higher doses, which causes tolerance in the long term.
Research in both animal and human has demonstrated that theacrine does not result in a fatigued crash or lead to tolerance build up over time. In a placebo-controlled study, theacrine demonstrated non-habituating effects in 60 healthy humans over 8 weeks of daily use at up to 300 mg/day.
Also unlike caffeine, theacrine doesn’t seem to affect blood pressure, cause anxiety, or lead to insomnia.
In addition, it may have benefits that caffeine doesn’t, such as decreasing inflammation and relieving pain.
However, these two compounds are more effective when taken together because caffeine increases the bioavailability and positive effects of theacrine.