Vitamin K is a derivative of a naphthoquinone group having the biological activity of chlorophyllin. Naturally occurring vitamins K1 and K2, vitamin K1 is widely found in green plants and is an important source of vitamin K in foods; vitamin K2 is mainly synthesized by intestinal bacteria. Synthetic vitamin K3, K4, K5, K7 and the like. Vitamin K2 is biologically active in animals, and both vitamin K1 and vitamin K3 are converted to vitamin K2 to function. The three forms of vitamin K are converted into vitamin K2 in the liver and are absorbed and utilized together with vitamin K2 synthesized by gastrointestinal microorganisms.
Vitamin K2 is a generic term for a series of terpene side chain compounds containing a 2-methyl-1,4-naphthoquinone core and a C3 position with a different number of isoprene structural units, depending on the side chain of the terpene. The number of carbon elements can be classified into K2 (10), K2 (20), K2 (35), K2 (40), and the like.
Vitamin K2 is a fat-soluble vitamin, a derivative of the naphthoquinone group with biological activity of chlorophyll, and is one of the important vitamins in the human body.
Vitamin K2 (35) is a vitamin K2 with 35 carbon elements in the side chain of the terpene; vitamin K2 (35) is also known as menaquinone-7, which is based on the side of the terpene with 7 isoprene The olefinic side chain is named. Vitamin K2 is the only biologically active form of vitamin K. It is used to accelerate blood clotting, maintain clotting time, and treat hemorrhagic disease caused by vitamin K deficiency.
2.Types of Vitamin K2 & Difference between MK-4 and MK-7
Vitamin K2 contributes to bone and cardiovascular health. Therefore, two vitamin K2 homologues, menaquinone-4 (MK-4) and menaquinone-7 (MK-7), have been used as nutrients by the food industry and as nutritional supplements to support bone and cardiovascular health.
Difference Between MK-4 & MK-7
Vitamin K2 Type
Absorption & Transfer
Rapidly removed from the liver by the same lipoprotein as a carrier
Redistributed primarily in the liver by low-density lipoproteins
Studies have shown that the side chain of vitamin K2 (MK-7) is longer than vitamin K2 (MK-4), for which it can be stored in the human body for a long time, and its bioavailability in extrahepatic tissues is higher
Effective Use Level
mg/d (mg), three times a day, 15 mg each time (equivalent to 45,000 micrograms per day), and is required to be taken 500 times more than vitamin K2 (MK-7)
μg/d grade (microgram level), once a day, 90 micrograms each time
Obtained by chemical synthesis
Naturally extracted or chemically synthesized
Osteoporosis, Improved arterial Calcification, Treatment of Parkinson's disease
MK-4 present in food does not contribute to the vitamin K status as measured by serum vitamin K levels. MK-7, however significantly increases serum MK-7 levels and therefore may be of particular importance for extrahepatic tissues.
Therefore, It can be seen that vitamin K2 (MK-7) far exceeds vitamin K2 (MK-4) in terms of biological activity, bioavailability and efficacy.
3.Specification of Vitamin K2
Vitamin K2 (i)(Menaquinone-7)
light yellow powder
Loss on drying
As Pb Cd Hg
≤ 0.1ppm ≤ 0.1 ppm ≤ 0.1 ppm ≤ 0.05 ppm
Count Yeast & Mold
Package & Storage
Carefully protect from light
4.Benefits & Applications of Vitamin K2
The health benefits of vitamin K2 go far beyond blood clotting, which is done by vitamin K1, and vitamin K2 also works synergistically with a number of other nutrients, including calcium and vitamin . It may help stave off chronic disease by:
Preventing cardiovascular disease
Ensuring healthy skin
Forming strong bones and improving bone health
Promoting brain function
Supporting growth and development
Helping to prevent cancer
1. Treatment of vitamin K2 deficiency hemorrhagic. 2. Calcium-introducing bone: Vitamin K2 has carboxylation of primary osteocalcin, which is secreted by osteoblasts, and becomes active osteocalcin, thereby promoting the deposition of calcium ions into the bone. If the body's vitamin K2 is sufficient, it can activate osteocalcin. The activated osteocalcin has a unique affinity for calcium ions, which can induce calcium into the bone and deposit calcium salts, thereby promoting bone mineralization. 3. Treatment and prevention of osteoporosis, vitamin K2 produces bone protein, and then together with calcium to form bone, increase bone density and prevent fracture.
4. Vitamin K2 can prevent liver cirrhosis from progressing to liver cancer. 5. Treatment of vitamin K2 deficiency hemorrhagic disease, promote the formation of prothrombin, accelerate blood clotting, maintain normal clotting time. 6. It has diuretic, strengthens the detoxification function of the liver, and can lower blood pressure.
A team led by neuroscientist Patrik Verstreken used vitamin K2 to successfully eliminate the effects of a genetic defect that causes Parkinson's disease. His research has brought new hope to patients with Parkinson's disease. Related papers are published in the journal Science.
Health Care Function Treatment and prevention of osteoporosis Vitamin K2 can prevent liver cirrhosis from progressing to liver cancer
Anti-tumor Mechanism The main role of vitamin K2 is to maintain the normal coagulation function of the body. In recent years, it has been found that vitamin K2 can induce apoptosis in leukemia and myelodysplastic syndromes of various solid tumors and blood systems such as hepatocellular carcinoma and ovarian cancer. It has obvious anti-tumor effect and synergistic effect with various anti-tumor drugs.
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